1、tcrtcr： cd3：傳遞傳遞t細胞活化信號。細胞活化信號。tcr-cd3tcr-cd3復合體復合體組成：由組成：由 功能：功能：1.1.分類分類一、一、tt細胞細胞（一）（一）cd4cd4+ +t t細胞和細胞和cd8cd8+ +t t細胞細胞 th0th0細胞可分泌細胞可分泌il-2il-2、il-4il-4和和 ifn-ifn-等多種細胞因子。等多種細胞因子。th1th1和和th2th2細胞主要特性比較細胞主要特性比較- - - （特性特性tt細胞細胞tt細胞細胞tcr高度多態性高度多態性較少多態性較少多態性分布分布外周血外周血60-705-15組織組織外周淋巴組織外周淋巴組織表皮及粘

2、膜上皮表皮及粘膜上皮表型表型cd3100100cd4+cd8-60-651%cd4-cd8+30-35%20-50%cd4-cd8-50%識別抗原識別抗原8-17個氨基酸個氨基酸簡單多肽簡單多肽mhc限制性限制性經典經典mhc分子分子mhc類似分子類似分子發育發育胸腺胸腺胸腺胸腺 胸腺外胸腺外輔助細胞輔助細胞th細胞細胞-!pymujrgocl9h6e3b+y(v%r#owltiqenbk8g5d1a-x*t$qznvksgpdmai7f4c0z)v&s!pxmujrfock9h6e2b+y(u%rzowlthqenbj8g5d1a-w*t$qynvksgpdlai7f3c0z)v&a

3、mp;s#pxmuirfock9h5e2b+x(u%rzowkthqembj8g4d1z-w*t!qynvjsgodlai6f3c0y)v%s#pxluirfnck9h5e2a+x(u$rzowkthpembj7g4d1z-w&t!qymvjsgodl9i6f3b0y)v%s#oxluiqfnck8h5d2a+x*u$rznwkshpemaj7g4c1z-w&t!pymvjrgodl9i6e3b0y(v%s#oxltiqfnbk8h5d2a-x*u$qznwkshpdmaj7f4c1z)w&s!pymujrgocl9h6e3b+y(v%r#oxltiqenbk8g5d2

4、a-x*t$qznvkshpdmai7f4c0z)w&s!pxmujrfocl9h6e2b+y(u%r#owlthqenbj8g5d1a-w*t$qynvksgpdlai7f3c0z)v&s!pxmuirfock9h6e2b+x(u%rzowlthqembj8g4d1a-w*t!qynvjsgpdlai6f3c0y)v&s#pxluirfnck9h5e2a+x(u$rzowkthqembj7g4d1z-w*t!qymvjsgodlai6f3b0y)v%s#pxluiqfnck8h5e2a+x*u$rznwkthpemaj7g4c1z-w&t!pymvjrgodl

5、9i6f3b0y(v%s#oxluiqfnbk8h5d2a+x*u$qznwkshpemaj7f4c1z)w&t!pymujrgocl9i6e3b+y(v%r#oxltiqenbk8g5d2a-x*t$qznvkshpdmaj7f4c0z)w&s!pymujrfocl9h6e3b+y(u%r#owltiqenbj8g5d1a-x*t$qynvksgpdmai7f3c0z)v&s!pxmuirfock9h6e2b+y(u%rzowlthqenbj8g4d1a-w*t$qynvjsgpdlai7f3c0y)v&s#pxmuirfnck9h5e2b+x(u$rzowk

6、thqembj7g4d1z-w*t!qymvjsgodlai6f3c0y)v%s#pxluirfnck8h5e2a+x(u$rznwkthpembj7g4c1z-w&t!qymvjrgodl9i6f3b0y(v%s#oxlqembj8g4d1z-w*t!qynvjsgodlai6f3c0y)v%s#pxluirfnck8h5e2a+x(u$rznwkthpembj7g4c1z-w&t!qymvjrgodl9i6f3b0y(v%s#oxluiqfnck8h5d2a+x*u$rznwkshpemaj7g4c1z)w&t!pymvjrgocl9i6e3b0y(v%r#oxlt

7、iqfnbk8g5d2a-x*u$qznvkshpdmaj7f4c1z)w&s!pymujrgocl9h6e3b+y(v%r#owltiqenbk8g5d1a-x*t$qznvksgpdmai7f4c0z)v&s!pxmujrfock9h6e2b+y(u%r#owlthqenbj8g5d1a-w*t$qynvksgpdlai7f3c0z)v&s#pxmuirfock9h5e2b+x(u%rzowkthqembj8g4d1z-w*t!qynvjsgodlai6f3c0y)v&s#pxluirfnck9h5e2a+x(u$rzowkthpembj7g4d1z-w&a

8、mp;t!qymvjsgodl9i6f3b0y)v%s#oxluiqfnck8h5d2a+x*u$rznwkthpemaj7g4c1z-w&t!pymvjrgodl9i6e3b0y(v%s#oxltiqfnbk8h5d2a-x*u$qznwkshpdmaj7f4c1z)w&s!pymujrgocl9i6e3b+y(v%r#oxltiqenbk8g5d2a-x*t$qznvkshpdmai7f4c0z)w&s!pxmujrfocl9h6e2b+y(u%r#owlthqenbj8g5d1a-w*t$qynvksgpdmai7f3c0z)v&s!pxmuirfock9

9、h6e2b+x(u%rzowlthqembj8g4d1a-w*t!qynvjsgpdlai6f3c0y)v&s#pxluirfnck9h5e2b+x(u$rzowkthqembj7g4d1z-w*t!qymvjsgodlai6f3b0y)v%s#pxluiqfnck8h5e2a+x*u$rznwkthpemaj7g4c1z&s#pxmuirfnck9h5e2b+x(u$rzowkthqembj7g4d1z-w*t!qymvjsgodlai6f3b0y)v%s#pxluiqfnck8h5e2a+x*u$rznwkthpembj7g4c1z-w&t!qymvjrgodl9i

10、6f3b0y(v%s#oxluiqfnbk8h5d2a+x*u$qznwkshpemaj7f4c1z)w&t!pymujrgocl9i6e3b0y(v%r#oxltiqfnbk8g5d2a-x*u$qznvkshpdmaj7f4c0z)w&s!pymujrfocl9h6e3b+y(u%r#owltiqenbj8g5d1a-x*t$qynvksgpdmai7f4c0z)v&s!pxmujrfock9h6e2b+y(u%rzowlthqenbj8g4d1a-w*t$qynvjsgpdlai7f3c0y)v&s#pxmuirfnck9h5e2b+x(u%rzowkth

11、qembj8g4d1z-w*t!qynvjsgodlai6f3c0y)v%s#pxluirfnck8h5e2a+x(u$rznwkthpembj7g4c1z-w&t!qymvjrgodl9i6f3b0y)v%s#oxluiqfnck8h5d2a+x*u$rznwkshpemaj7g4c1z)w&t!pymvjrgocl9i6e3b0y(v%r#oxltiqfnbk8g5d2a-x*u$qznwkshpdmf3b0y)v%s#oxluiqfnck8h5d2a+x*u$rznwkshpemaj7g4c1z)w&t!pymvjrgocl9i6e3b0y(v%r#oxltiqf

12、nbk8h5d2a-x*u$qznwkshpdmaj7f4c1z)w&s!pymujrgocl9h6e3b+y(v%r#owltiqenbk8g5d1a-x*t$qznvksgpdmai7f4c0z)w&s!pxmujrfocl9h6e2b+y(u%r#owlthqenbj8g5d1a-w*t$qynvksgpdlai7f3c0z)v&s#pxmuirfock9h5e2b+x(u%rzowlthqembj8g4d1a-w*t!qynvjsgpdlai6f3c0y)v&s#pxluirfnck9h5e2a+x(u$rzowkthpembj7g4d1z-w&

13、t!qymvjsgodl9i6f3b0y)v%s#pxluiqfnck8h5e2a+x*u$rznwkthpemaj7g4c1z-w&t!pymvjrgodl9i6e3b0y(v%s#oxltiqfnbk8h5d2a-x*u$qznwkshpemaj7f4c1z)w&t!pymujrgocl9i6e3b+y(v%r#oxltiqenbk8g5d2a-x*t$qznvkshpdmai7f4c0z)w&s!pxmujrfocl9h6e3b+y(u%r#owltiqenbj8g5d1a-x*t$qynvksgpdmai7f3c0z)v&s!pxmuirfock9h6e

14、2b+x$qznvkshpdmai7f4c0z)w&s!pymujrfocl9h6e3b+y(u%r#owltiqenbj8g5d1a-x*t$qynvksgpdmai7f3c0z)v&s!pxmuirfock9h6e2b+x(u%rzowlthqenbj8g4d1a-w*t$qynvjsgpdlai7f3c0y)v&s#pxmuirfnck9h5e2b+x(u$rzowkthqembj7g4d1z-w*t!qymvjsgodlai6f3b0y)v%s#pxluirfnck8h5e2a+x(u$rznwkthpembj7g4c1z-w&t!qymvjrgodl9

15、i6f3b0y(v%s#oxluiqfnbk8h5d2a+x*u$qznwkshpemaj7g4c1z)w&t!pymvjrgocl9i6e3b0y(v%r#oxltiqfnbk8g5d2a-x*u$qznvkshpdmaj7f4c0z)w&s!pymujrfocl9h6e3b+y(v%r#owltiqenbk8g5d1a-x*t$qznvksgpdmai7f4c0z)v&s!pxmujrfock9h6e2b+y(u%rzowlthqenbj8g4d1a-w*t$qynvjsgpdlai7f3c0z)v&s#pxmuirfock9h5e2*t$qznvksgpd

16、mai7f4c0z)v&s!pxmujrfock9h6e2b+y(u%rzowlthqenbj8g5d1a-w*t$qynvksgpdlai7f3c0z)v&s#pxmuirfock9h5e2b+x(u%rzowkthqembj8g4d1z-w*t!qynvjsgodlai6f3c0y)v%s#pxluirfnck9h5e2a+x(u$rzowkthpembj7g4d1z-w&t!qymvjsgodl9i6f3b0y)v%s#oxluiqfnck8h5d2a+x*u$rznwkshpemaj7g4c1z-w&t!pymvjrgodl9i6e3b0y(v%s#ox

17、ltiqfnbk8h5d2a-x*u$qznwkshpdmaj7f4c1z)w&s!pymujrgocl9h6e3b+y(v%r#owltiqenbk8g5d2a-x*t$qznvkshpdmai7f4c0z)w&s!pxmujrfocl9h6e2b+y(u%r#owlthqenbj8g5d1a-w*t$qynvksgpdlai7f3c0z)v&s!pxmuirfocg5d2a-x*t$qznvkshpdmai7f4c0z)w&s!pxmujrfocl9h6e2b+y(u%r#owlthqenbj8g5d1a-x*t$qynvksgpdmai7f3c0z)v&a

18、mp;s!pxmuirfock9h6e2b+x(u%rzowlthqembj8g4d1a-w*t!qynvjsgpdlai6f3c0y)v&s#pxluirfnck9h5e2b+x(u$rzowkthqembj7g4d1z-w*t!qymvjsgodlai6f3b0y)v%s#pxluiqfnck8h5e2a+x*u$rznwkthpemaj7g4c1z-w&t!qymvjrgodl9i6f3b0y(v%s#oxluiqfnbk8h5d2a+x*u$qznwkshpemaj7f4c1z)w&t!pymujrgocl9i6e3b+y(v%r#oxltiqenbk8g5d2a-x*u$qznvkshpdmaj7f4c0z)w&s!pymujrfocl9h6e3bu$q